William Anzalone was educated in Brooklyn Public Schools and graduated from the Massachusetts Institute of Technology with a BA in Architecture in 1958. He won the Rotch Prize in Architecture in 1958 and practiced architecture in Massachusetts from 1958-1959.
Anzalone came to Houston, Texas in July 1959, and began teaching at the University of Houston. He also taught briefly at the Museum of Fine Arts Houston School.
William Anzalone has had many one man shows and group shows in Texas, Massachusetts, and New York.